Article
Stability of microsatellites and minisatellites in Bloom syndrome, a human syndrome of genetic instability.
Mutation research - 2 Apr 1996
Foucault F, Buard J, Praz F, Jaulin C, Stoppa-Lyonnet D, Vergnaud G, Amor-Guéret M
Abstract excerpt
Bloom syndrome (BS) is a human cancer-prone genetic disorder essentially characterized by a generalized genetic instability including a high level of sister chromatid exchanges (SCEs). Although mutator and hyper-Rec phenotypes of BS cells present analogies with those of bacteria and yeast defecti...
Topics
- Bacteria
- Base Sequence
- Bloom Syndrome
- Cell Line
- Clone Cells
- DNA Primers
- DNA Repair
- DNA, Satellite
- Genetic Markers
- HeLa Cells
- Humans
- Male
- Microsatellite Repeats
- Minisatellite Repeats
- Molecular Sequence Data
- Phenotype
- Polymerase Chain Reaction
- Saccharomyces cerevisiae