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Article

The mutational impact of Illudin S on human cells.

DNA repair - 1 Feb 2023

Casimir Lisa, Zimmer Samuel, Racine-Brassard Félix, Jacques Pierre-Étienne, Maréchal Alexandre

Abstract excerpt

Illudin S (ILS) is a fungal sesquiterpene secondary metabolite with potent genotoxic and cytotoxic properties. Early genetic studies and more recent genome-wide CRISPR screens showed that Illudin-induced lesions are preferentially repaired by transcription-coupled nucleotide excision repair (TC-NER) with some contribution from post-replication repair pathways. In line with these results, Irofulven, a...

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Identifiers

PMID: 36566616
DOI: 10.1016/j.dnarep.2022.103433

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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