Article
Unique sequences in the guinea pig glucocorticoid receptor induce constitutive transactivation and decrease steroid sensitivity.
Molecular endocrinology (Baltimore, Md.) - 1 Apr 1994
Keightley M C, Fuller P J
Abstract excerpt
Previous attempts to characterize the structural determinants required for binding of cortisol by the glucocorticoid receptor (GR) have proved difficult since almost all modifications of the ligand binding domain (LBD) of GRs either eliminate or greatly decrease steroid binding. The guinea pig, a...
Topics
- 8-Bromo Cyclic Adenosine Monophosphate
- Amino Acid Sequence
- Animals
- Cloning, Molecular
- Cysteine
- Dexamethasone
- Drug Resistance
- Gene Expression Regulation
- Genetic Vectors
- Guinea Pigs
- Haplorhini
- Humans
- Hydrocortisone
- Mice
- Mifepristone
- Molecular Sequence Data
- Mutation
- Phylogeny