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Article

Unique sequences in the guinea pig glucocorticoid receptor induce constitutive transactivation and decrease steroid sensitivity.

Molecular endocrinology (Baltimore, Md.) - 1 Apr 1994

Keightley M C, Fuller P J

Abstract excerpt

Previous attempts to characterize the structural determinants required for binding of cortisol by the glucocorticoid receptor (GR) have proved difficult since almost all modifications of the ligand binding domain (LBD) of GRs either eliminate or greatly decrease steroid binding. The guinea pig, a New World hystricomorph with a phylogeny the subject of recent dispute, is corticoresistant due to a GR that has...

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PMID: 8052264
DOI: 10.1210/mend.8.4.8052264

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