Current concepts in glucocorticoid resistance.

doi:10.1016/j.steroids.2012.05.007

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Article

Current concepts in glucocorticoid resistance.

Steroids - 1 Sept 2012

Yang Nan, Ray David W, Matthews Laura C

Abstract excerpt

Glucocorticoids (GCs) are the most potent anti-inflammatory agents known. A major factor limiting their clinical use is the wide variation in responsiveness to therapy. The high doses of GC required for less responsive patients means a high risk of developing very serious side effects. Variation in sensitivity between individuals can be due to a number of factors. Congenital, generalized GC resistance is very...

Topics

Anti-Inflammatory Agents
Cellular Microenvironment
Chronic Disease
Cytokines
Drug Resistance
Glucocorticoids
Humans
Hypoxia
Inflammation
Mutation
Oxidative Stress
Polymorphism, Genetic
Receptors, Glucocorticoid
Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 22728894
DOI: 10.1016/j.steroids.2012.05.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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