Article
Mutations flanking the polyglutamine repeat in the modulatory domain of rat glucocorticoid receptor lead to an increase in affinity for hormone.
Endocrine research - 1 Aug 2002
Heeley Robert P, Rusconi Sandro G, Sutcliffe Roger G, Kenyon Christopher J
Abstract excerpt
A polyglutamine repeat in the N-terminus of the rat glucocorticoid receptor shows polymorphism, with variants of Q2RQ5, Q2RQ15-21. We investigated whether these natural polymorphisms affect receptor function, and whether alleles with polyglutamine repeats shorter than Q2RQ5, between Q2RQ6-14, or longer than Q2RQ21 are not found naturally because they encode a dysfunctional receptor. Ligand binding and...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Binding, Competitive
- Cell Line
- Cloning, Molecular
- Corticosterone
- Dexamethasone
- Glucocorticoids
- Hormones
- Molecular Sequence Data
- Mutation
- Peptides
- Protein Structure, Tertiary