Cortisol resistance and the guinea pig glucocorticoid receptor.

doi:10.1016/0039-128x(94)00014-4

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Article

Cortisol resistance and the guinea pig glucocorticoid receptor.

Steroids - 1 Jan 1995

Keightley M C, Fuller P J

Abstract excerpt

The guinea pig has been employed as a model to study the structure/function relationships of the glucocorticoid receptor (GR), and to determine the regions of the receptor important for binding hormone and antihormone. Guinea pigs have high levels of circulating cortisol and GR with a approximately 20-fold lower affinity for dexamethasone than mouse GR. Cloning and sequencing of guinea pig GR has identified 24...

Topics

Amino Acid Sequence
Animals
Base Sequence
Cloning, Molecular
DNA Primers
DNA, Complementary
Drug Resistance
Genetic Code
Guinea Pigs
Humans
Mice
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Polymerase Chain Reaction

Rats

Receptors, Glucocorticoid

Sequence Homology, Nucleic Acid

Structure-Activity Relationship

Source

Open in PubMed

Identifiers

PMID: 7792823
DOI: 10.1016/0039-128x(94)00014-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7792823-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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