Article
Persistent augmentation of natural-killer- and T-cell-mediated cytotoxicity in peripheral blood mononuclear cells pulsed in vitro with high-dose recombinant interleukin-2 prior to culturing with a low maintenance dose.
Cancer immunology, immunotherapy : CII - 1 Jul 1994
Palmer P A, Scharenberg J G, von Blomberg B M, Stam A G, Meijer C J, Roest G J, Franks C R, Scheper R J
Abstract excerpt
The toxicity of high-dose recombinant interleukin-2 (rIL-2) treatment limits its use in tumour therapies. This paper describes in vitro studies of whether a single, peak rIL-2 dose, followed by low maintenance doses, could enhance the cytotoxic potential of peripheral blood mononuclear cells (PBMC) without inducing a significant sustained release of secondary cytokines, known to contribute to undesirable...
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