Persistent augmentation of natural-killer- and T-cell-mediated cytotoxicity in peripheral blood mononuclear cells pulsed in vitro with high-dose recombinant interleukin-2 prior to culturing with a low maintenance dose.

doi:10.1007/BF01517178

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Article

Persistent augmentation of natural-killer- and T-cell-mediated cytotoxicity in peripheral blood mononuclear cells pulsed in vitro with high-dose recombinant interleukin-2 prior to culturing with a low maintenance dose.

Cancer immunology, immunotherapy : CII - 1 Jul 1994

Palmer P A, Scharenberg J G, von Blomberg B M, Stam A G, Meijer C J, Roest G J, Franks C R, Scheper R J

Abstract excerpt

The toxicity of high-dose recombinant interleukin-2 (rIL-2) treatment limits its use in tumour therapies. This paper describes in vitro studies of whether a single, peak rIL-2 dose, followed by low maintenance doses, could enhance the cytotoxic potential of peripheral blood mononuclear cells (PBM...

Topics

Animals
Cells, Cultured
Culture Media
Cytokines
Cytotoxicity, Immunologic
Dose-Response Relationship, Drug
Drug Resistance
Humans
Interleukin-2
Killer Cells, Natural
Leukocytes, Mononuclear
Lymphocyte Activation
Mice

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Phenotype

Recombinant Proteins

Sensitivity and Specificity

T-Lymphocytes

Tumor Cells, Cultured

Source

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Identifiers

PMID: 8044824
DOI: 10.1007/BF01517178
PMCID: PMC11038947

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8044824-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.