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Article

Nuclear localization of Vpr is crucial for the efficient replication of HIV-1 in primary CD4+ T cells.

Virology - 1 Oct 2004

Iijima Sayuki, Nitahara-Kasahara Yuko, Kimata Kiyonori, Zhong Zhuang Wen, Kamata Masakazu, Isogai Maya, Miwa Masanao, Tsunetsugu-Yokota Yasuko, Aida Yoko

Abstract excerpt

The human immunodeficiency virus type 1 (HIV-1) accessory protein Vpr appears to make a substantial contribution to the replication of HIV-1 in established T cell lines when HIV-1 is present at very low multiplicities of infection. However, the role of Vpr in viral replication in primary CD4+ T cells remains to be clarified. In this study, we generated a panel of viruses that encoded mutant forms of Vpr that...

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Identifiers

PMID: 15351213
DOI: 10.1016/j.virol.2004.06.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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