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Article

A mutant toxin of Vibrio parahaemolyticus thermostable direct hemolysin which has lost hemolytic activity but retains ability to bind to erythrocytes.

Infection and immunity - 1 Aug 1994

Tang G Q, Iida T, Yamamoto K, Honda T

Abstract excerpt

A mutant toxin, R7, of thermostable direct hemolysin (TDH) with a single amino acid substitution at glycine 62 was analyzed. The hemolytic activity of R7 decreased to less than 1/1,000 of that of wild-type TDH, and its mouse lethality was undetectable. This mutant toxin, however, showed a marked inhibitory effect on hemolysis by wild-type TDH. Enzyme immunoassay and flow cytometric analysis demonstrated that R7...

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Identifiers

PMID: 8039901
DOI: 10.1128/iai.62.8.3299-3304.1994
PMCID: PMC302959

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Source receipt: pubmed, retrieved 7 Sept 2026.

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