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Article

Mechanisms of assembly and cellular interactions for the bacterial genotoxin CDT.

PLoS pathogens - 1 Nov 2005

Nesic Dragana, Stebbins C Erec

Abstract excerpt

Many bacterial pathogens that cause different illnesses employ the cytolethal distending toxin (CDT) to induce host cell DNA damage, leading to cell cycle arrest or apoptosis. CDT is a tripartite holotoxin that consists of a DNase I family nuclease (CdtB) bound to two ricin-like lectin domains (CdtA and CdtC). Through the use of structure-based mutagenesis, biochemical and cellular toxicity assays, we have...

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Identifiers

PMID: 16304609
DOI: 10.1371/journal.ppat.0010028
PMCID: PMC1287909

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