Article
Saccharomyces cerevisiae mutants sensitive to the antimalarial and antiarrhythmic drug, quinidine.
FEMS microbiology letters - 1 Jun 1994
Conklin D S, Culbertson M R, Kung C
Abstract excerpt
Mutations at three loci in Saccharomyces cerevisiae have been shown to confer increased sensitivity to the antimalarial and antiarrhythmic alkaloid, quinidine. Two of these groups are composed of strains carrying recessive mutations, the other group contains two dominant alleles. The largest complementation group has been designated QDS1, for increased quinidine-sensitivity. Exposure of qds1 cells to lethal...
Topics
- Alleles
- Drug Resistance
- Mutation
- Proprotein Convertases
- Quinidine
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Subtilisins