Interpreting the effects of site-directed mutagenesis on active transport systems.

doi:10.1016/0005-2736(94)90346-8

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Article

Interpreting the effects of site-directed mutagenesis on active transport systems.

Biochimica et biophysica acta - 13 Jul 1994

Krupka R M

Abstract excerpt

Single amino acid substitutions in the lactose permease of Escherichia coli are known to elicit behaviour, such as the transformation of an active into a passive system, not explained by current co-transport models. The behaviour, it is shown, can be explained by an expanded reaction scheme that...

Topics

Biological Transport, Active
Escherichia coli
Escherichia coli Proteins
Membrane Transport Proteins
Models, Chemical
Monosaccharide Transport Proteins
Mutagenesis, Site-Directed
Mutation
Protein Conformation
Symporters

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