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Article

Mathematical modeling of the apo and holo transcriptional regulation in Escherichia coli.

Molecular bioSystems - 1 Apr 2015

Alvarez-Vasquez Fernando J, Freyre-González Julio A, Balderas-Martínez Yalbi I, Delgado-Carrillo Mónica I, Collado-Vides Julio

Abstract excerpt

Transcription factors (TFs) modulate gene expression as a consequence of internal or exogenous changes in cell signaling. TFs can bind to DNA either with their effector bound (holo conformation), or as free proteins (apo conformation). With the aim of contributing to the understanding of the evolutionary fitness and organizational principles behind the different TF conformations, we inquire into the origins of...

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PMID: 25683745
DOI: 10.1039/c4mb00561a

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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