Article
Wild-type but not mutant APC associates with the microtubule cytoskeleton.
Cancer research - 15 Jul 1994
Smith K J, Levy D B, Maupin P, Pollard T D, Vogelstein B, Kinzler K W
Abstract excerpt
The adenomatous polyposis coli protein (APC) is mutated in familial adenomatous polyposis patients as well as in sporadic colorectal tumors. In an attempt to further understand the function of APC, the subcellular localization of APC was examined. Wild-type and mutant forms of APC were expressed...
Topics
- 3T3 Cells
- Adenomatous Polyposis Coli Protein
- Animals
- Cytoskeletal Proteins
- Humans
- Mice
- Microtubule Proteins
- Microtubules
- Mutation