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Article

Wild-type but not mutant APC associates with the microtubule cytoskeleton.

Cancer research - 15 Jul 1994

Smith K J, Levy D B, Maupin P, Pollard T D, Vogelstein B, Kinzler K W

Abstract excerpt

The adenomatous polyposis coli protein (APC) is mutated in familial adenomatous polyposis patients as well as in sporadic colorectal tumors. In an attempt to further understand the function of APC, the subcellular localization of APC was examined. Wild-type and mutant forms of APC were expressed in mammalian cells and protein detected by immunofluorescence using monoclonal and polyclonal antibodies. Staining of...

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Source

Identifiers

PMID: 8033082

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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