Article
Critical base substitutions that affect the splicing and/or homing activities of the group I intron bi2 of yeast mitochondria.
Molecular & general genetics : MGG - 1 Sept 2000
Szczepanek T, Jamoussi K, Lazowska J
Abstract excerpt
The second intron (bi2) of the cyt b gene from related Saccharomyces species has an extraordinarily conserved sequence and can have different functions in wild-type cells. The protein encoded by the S. cerevisiae intron functions as a maturase to promote intron splicing, while the homologous S. capensis intron encodes a bifunctional protein that acts both as a maturase and as a homing endonuclease (I-ScaI)...
Topics
- Amino Acid Motifs
- Conserved Sequence
- Cytochrome b Group
- Endoribonucleases
- Introns
- Mitochondria
- Mutation
- Mutation, Missense
- RNA Splicing
- Yeasts