Article
The role of spontaneous cap domain mutations in haloalkane dehalogenase specificity and evolution.
The Journal of biological chemistry - 1 Jul 1994
Pries F, van den Wijngaard A J, Bos R, Pentenga M, Janssen D B
Abstract excerpt
The first step in the utilization of the xenobiotic chlorinated hydrocarbon 1,2-dichloroethane by Xanthobacter autotrophicus is catalyzed by haloalkane dehalogenase (Dh1A). The enzyme hydrolyses 1-haloalkanes to the corresponding alcohols. This allows the organism to grow also on short-chain (C2-...
Topics
- Amino Acid Sequence
- Base Sequence
- Biological Evolution
- Corynebacterium
- DNA, Bacterial
- Hexanes
- Hydrocarbons, Chlorinated
- Hydrolases
- Molecular Sequence Data
- Mutation
- Protein Conformation
- Pseudomonas
- Substrate Specificity