Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tyrosine kinase inhibitor-induced differentiation of K-562 cells: alterations of cell cycle and cell surface phenotype.

Cancer letters - 15 Jun 1994

Hunáková L, Sedlák J, Klobusická M, Duraj J, Chorváth B

Abstract excerpt

Protein tyrosine kinase (PTK) inhibitor herbimycin A inhibited proliferation, induced accumulation of cells in the G0/G1 phase of the cell cycle and a marked increae of hemoglobin-producing human leukemic K-562 cells in vitro. The isoflavonoid PTK- and topoisomerase II inhibitor genistein produced a similar effect with the accumulation of cells in the G2/M phase of cell cycle. Genistein potentiated the effect of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Surface
Share to Cell Cycle
Share to Cell Differentiation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hemoglobins

Share to Phenotype

Share to Protein-Tyrosine Kinases

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 8019992
DOI: 10.1016/0304-3835(94)90168-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Tyrosine kinase inhibitor-induced differentiation of K-562 cells: alterations of cell cycle and cell surface phenotype.PMID 8019992Read ↗

Effects of genistein and daidzein on the cell growth, cell cycle, and differentiation of human and murine melanoma cells1 1The abbreviations used are: BSA, bovine serum albumin; FBS, fetal bovine serum; ECM, extracellular matrix; DMSO, dimethyl sulfoxide; PTK, protein tyrosine kinase.Semantic proximity Read ↗

Induction of erythroid differentiation of human K562 cells by cisplatin analogsSemantic proximity Read ↗

Inhibition of anchorage-independent growth of tumor cells by IT-62-B, a new anthracycline.Semantic proximity Read ↗

Phenotypic reversion induced by anthracyclines in ras oncogene-expressed cells; structure-activity relationships.Semantic proximity Read ↗

Structure-activity Relationships of Flavonoids and the Induction of Granulocytic- or Monocytic-Differentiation in HL60 Human Myeloid Leukemia CellsSemantic proximity Read ↗

Cyclin-dependent kinase 5 activity enhances monocytic phenotype and cell cycle traverse in 1,25-dihydroxyvitamin D3-treated HL60 cells.Semantic proximity Read ↗

Cell cycle checkpoint revolution: targeted therapies in the fight against malignant tumorsSemantic proximity Read ↗

Cell cycle checkpoint proteins and cellular response to treatment by anticancer agents.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.