Tyrosine kinase inhibitor-induced differentiation of K-562 cells: alterations of cell cycle and cell surface phenotype.

doi:10.1016/0304-3835(94)90168-6

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Article

Tyrosine kinase inhibitor-induced differentiation of K-562 cells: alterations of cell cycle and cell surface phenotype.

Cancer letters - 15 Jun 1994

Hunáková L, Sedlák J, Klobusická M, Duraj J, Chorváth B

Abstract excerpt

Protein tyrosine kinase (PTK) inhibitor herbimycin A inhibited proliferation, induced accumulation of cells in the G0/G1 phase of the cell cycle and a marked increae of hemoglobin-producing human leukemic K-562 cells in vitro. The isoflavonoid PTK- and topoisomerase II inhibitor genistein produced a similar effect with the accumulation of cells in the G2/M phase of cell cycle. Genistein potentiated the effect of...

Topics

Animals
Antigens, Surface
Benzoquinones
Cell Cycle
Cell Differentiation
Genistein
Hemoglobins
Humans
Isoflavones
Lactams, Macrocyclic
Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Phenotype

Protein-Tyrosine Kinases

Quinones

Rifabutin

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 8019992
DOI: 10.1016/0304-3835(94)90168-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8019992-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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