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Cell cycle checkpoint proteins and cellular response to treatment by anticancer agents.

Cell cycle (Georgetown, Tex.) - 1 Jan 2004

Damia Giovanna, Broggini Massimo

Abstract excerpt

The response of cancer cells to treatment with anticancer agents is mediated in part by proteins controlling both the cell cycle progression and the genomic integrity, including p53, p73 and checkpoint proteins chk1 and chk2. We here summarized the cellular functions of these proteins, their alterations in human tumors and the impact of their mutations/alterations on cellular response to treatment, Particular...

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PMID: 14657665

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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