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Article

A physiologically based pharmacokinetic computer model for human pregnancy

1 Feb 1994

Abstract excerpt

A physiologically based pharmacokinetic (PBPK) model for human pregnancy must incorporate many factors that are not usually encountered in PBPK models of mature animals. Models for pregnancy must include the large changes that take place in the mother, the placenta and the embryo/fetus over the period of pregnancy. The embryo/fetal weight change was modeled using the Gompertz equation for growth which gave a good...

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PMID: 8016750
DOI: 10.1002/tera.1420490205

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