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Mechanisms regulating toxicant disposition to the embryo during early pregnancy: An interspecies comparison

1 Dec 2004

Abstract excerpt

The dose of toxicant reaching the embryo is a critical determinant of developmental toxicity, and is likely to be a key factor responsible for interspecies variability in response to many test agents. This review compares the mechanisms regulating disposition of toxicants from the maternal circulation to the embryo during organogenesis in humans and the two species used predominantly in regulatory developmental...

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PMID: 15662707
DOI: 10.1002/bdrc.20027

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