Article
Clinical and biological implications of partial tandem duplication of the MLL gene in acute myeloid leukemia without chromosomal abnormalities at 11q23.
Leukemia - 1 Feb 2002
Shiah H-S, Kuo Y-Y, Tang J-L, Huang S-Y, Yao M, Tsay W, Chen Y-C, Wang C-H, Shen M-C, Lin D-T, Lin K-H, Tien H-F
Abstract excerpt
The clinical and biological features of acute myeloid leukemia (AML) with 11q23/MLL translocations are well known, but the characteristics of AML with partial tandem duplication of the MLL gene have not been explored comprehensively. In this study, MLL duplication was analyzed, in 81 AML patients without chromosomal abnormalities at 11q23, using Southern blotting, genomic DNA polymerase chain reaction (PCR),...
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