Article
Phenotypic and genotypic characterization of acyclovir-resistant varicella-zoster viruses isolated from persons with AIDS.
The Journal of infectious diseases - 1 Jul 1994
Boivin G, Edelman C K, Pedneault L, Talarico C L, Biron K K, Balfour H H
Abstract excerpt
Phenotypic and genotypic analyses were done on 17 varicella-zoster virus (VZV) isolates recovered from 10 persons with AIDS (mean CD4 cell count, 16.4/mm3) who had chronic VZV lesions. Eleven acyclovir-resistant isolates were recovered from 10 patients after a mean of 20.1 weeks of therapy. Six s...
Topics
- AIDS-Related Opportunistic Infections
- Acyclovir
- Amino Acid Sequence
- Base Sequence
- Cells, Cultured
- DNA, Viral
- Drug Resistance, Microbial
- Genotype
- Herpes Zoster
- Herpesvirus 3, Human
- Humans
- Molecular Sequence Data
- Phenotype
- Polymerase Chain Reaction
- Thymidine Kinase