Possible role of HLA in hepatotoxicity. An exploratory study in 71 patients with drug-induced idiosyncratic hepatitis.

doi:10.1016/s0168-8278(94)80004-9

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Article

Possible role of HLA in hepatotoxicity. An exploratory study in 71 patients with drug-induced idiosyncratic hepatitis.

Journal of hepatology - 1 Mar 1994

Berson A, Fréneaux E, Larrey D, Lepage V, Douay C, Mallet C, Fromenty B, Benhamou J P, Pessayre D

Abstract excerpt

Possible associations between particular human leucocyte antigen molecules and immunoallergic hepatitis have been suggested previously (HLA-A11 in halothane hepatitis, HLA-DR6 and DR2 in nitrofurantoin hepatitis, HLA-B8 in clometacin hepatitis). In this study the HLA haplotype was determined in 7...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Chemical and Drug Induced Liver Injury
Chlorpromazine
Diclofenac
Female
HLA Antigens
HLA-A Antigens
HLA-A11 Antigen
HLA-B8 Antigen
HLA-DR2 Antigen
HLA-DR6 Antigen
Halothane
Haplotypes
Humans
Male

Source

Open in PubMed

Identifiers

PMID: 8014443
DOI: 10.1016/s0168-8278(94)80004-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8014443-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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