Article
HLA-A*11:01 is associated with levetiracetam-induced psychiatric adverse events.
PloS one - 1 Jan 2018
Yang Tae-Won, Moon Jangsup, Kim Tae-Joon, Jun Jin-Sun, Lim Jung-Ah, Lee Soon-Tae, Jung Keun-Hwa, Park Kyung-Il, Jung Ki-Young, Chu Kon, Lee Sang Kun
Abstract excerpt
Levetiracetam (LEV) is effective for focal and generalized epilepsy and is used worldwide because of its relatively few drug interactions and favorable tolerability. However, some psychiatric adverse events (PAEs) have been reported, resulting in drug withdrawal. The pathophysiology of LEV-induced PAE has not yet been elucidated. In this study, we investigated the relationship between PAEs and human leukocyte...
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