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Article

HLA-B*53:01 Is a Significant Risk Factor of Liver Injury due to Phenytoin and Other Antiepileptic Drugs in African Americans.

The American journal of gastroenterology - 1 Jan 2024

Nicoletti Paola, Dellinger Andrew, Li Yi-Ju, Barnhart Huiman, Phillips Elizabeth, Chalasani Naga

Abstract excerpt

INTRODUCTION: To investigate human leukocyte antigen alleles associated with liver injury due to antiepileptic drugs (AEDs) in African Americans (AA). METHODS: In this study, 21 AA with AED drug-induced liver injury (DILI), 176 AA with DILI due to non-AEDs, and 5816 AA population controls were included. RESULTS: HLA-B*53:01 was significantly associated with aromatic AED-DILI (odds ratio: 4.52, 95% confidence...

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Alleles
Anticonvulsants
Black or African American
Chemical and Drug Induced Liver Injury
HLA-B Antigens

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PMID: 37552102
DOI: 10.14309/ajg.0000000000002454
PMCID: PMC10841235

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