Article
Dependence of protein stability on the structure of the denatured state: free energy calculations of I56V mutation in human lysozyme.
Biophysical journal - 1 Nov 1998
Sugita Y, Kitao A
Abstract excerpt
Free energy calculations were carried out to understand the effect of the I56V mutation of human lysozyme on its thermal stability. In the simulation of the denatured state, a short peptide including the mutation site in the middle is employed. To study the dependence of the stability on the dena...
Topics
- Enzyme Stability
- Humans
- Models, Molecular
- Molecular Conformation
- Muramidase
- Mutation
- Protein Denaturation
- Thermodynamics