Article
Association of a novel high oxygen affinity haemoglobin variant with delta beta thalassaemia.
British journal of haematology - 1 Jan 1994
Rochette J, Barnetson R, Kiger L, Kister J, Littlewood T J, Webster R, Poyart C, Thein S L
Abstract excerpt
We report an uncommon association of delta beta thalassaemia and a haemoglobin (Hb) variant with high oxygen affinity in an Asian Indian family. Minimal polycythaemia was seen in a heterozygote for this novel Hb variant, Hb Headington (beta 72 (E16) Ser-->Arg), while compound heterozygosity for H...
Topics
- Adult
- Base Sequence
- Blotting, Southern
- DNA
- Female
- Globins
- Hemoglobins, Abnormal
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Oxygen
- Polymerase Chain Reaction
- beta-Thalassemia