Article
Characterization of hemoglobin bassett (alpha94Asp-->Ala), a variant with very low oxygen affinity.
American journal of hematology - 1 Nov 2004
Abdulmalik Osheiza, Safo Martin K, Lerner Norma B, Ochotorena Josiree, Daikhin Evgueni, Lakka Vinaysagar, Santacroce Rosa, Abraham Donald J, Asakura Toshio
Abstract excerpt
Hemoglobin (Hb) Bassett, an abnormal Hb variant with a markedly reduced oxygen affinity, was discovered in a Caucasian (Anglo-Saxon) male child who experienced episodes of cyanosis. Cation-exchange and reversed-phase (RP) high-performance liquid chromatography (HPLC) showed that the patient has a...
Topics
- Alanine
- Amino Acid Substitution
- Aspartic Acid
- Child
- Chromatography, Ion Exchange
- Crystallography, X-Ray
- Hemoglobin A
- Hemoglobins, Abnormal
- Humans
- Hydrogen-Ion Concentration
- Male
- Models, Molecular
- Mutation
- Oxygen
- Oxyhemoglobins
- Partial Pressure
- Protein Subunits