Article
Hb Howick [beta 37(C3)Trp-->Gly]: a new high oxygen affinity variant of the alpha 1 beta 2 contact.
Hemoglobin - 1 Dec 1993
Owen M C, Ockelford P A, Wells R M
Abstract excerpt
Hb Howick or beta 37(C3) Trp-->Gly is a newly described hemoglobin variant found in an adult male. Hematological data and stability by the isopropanol stability test were normal. The abnormal variant comprised 29% of total hemoglobin and migrated in the Hb D position on cellulose acetate at pH 8.6, and in the Hb F position on citrate agar (pH 6.0). Oxygen dissociation studies on the whole blood showed the variant...
Topics
- Adult
- Amino Acids
- Genetic Variation
- Globins
- Hemoglobins, Abnormal
- Humans
- Male
- Models, Molecular
- Oxygen
- Peptide Mapping
- Protein Binding