Article
Hb-Alberta or alpha2beta2 (101(G3) Glu replaced by Gly), a new high-oxygen-affinity hemoglobin variant causing erythrocytosis.
Hemoglobin - 1 Jan 2000
Mant M J, Salkie M L, Cope N, Appling F, Bolch K, Jayalakshmi M, Gravely M, Wilson J B, Huisman T H
Abstract excerpt
Hb-Alberta has been found in a 51 year old Caucasian male with erythrocytosis. The substitution in this variant involves the glutamyl residue in position 101(G3) of the beta chain which is replaced by a glycyl residue. Hb-Alberta accounts for about 45% in the heterozygote, and readily forms hybrid tetramers with other hemoglobins. The oxygen affinity of Hb-Alberta is greatly increased, its Bohr effect reduced,...
Topics
- Alberta
- Amino Acids
- Electrophoresis, Starch Gel
- Genetic Variation
- Glutamine
- Hemoglobins, Abnormal
- Humans
- Lysine
- Male
- Middle Aged
- Oxygen