Article
Somatic NF2 gene mutations in familial and non-familial vestibular schwannoma.
Human molecular genetics - 1 Feb 1994
Irving R M, Moffat D A, Hardy D G, Barton D E, Xuereb J H, Maher E R
Abstract excerpt
Vestibular schwannoma occurs both as a sporadic tumour and in the dominantly inherited familial cancer syndrome neurofibromatosis type 2 (NF2). The gene for NF2 has recently been isolated on chromosome 22, and the demonstration of inactivating germline mutations in NF2 patients and NF2 associated tumours suggests that it act as a tumour suppressor. We have investigated 85 sporadic and 2 NF2 associated vestibular...
Topics
- Adult
- Aged
- Base Sequence
- Codon
- Cranial Nerve Neoplasms
- Female
- Genes, Neurofibromatosis 2
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation