Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypic modulation of cultured vascular smooth muscle cells: a functional analysis focusing on MLC and ERK1/2 phosphorylation.

Molecular and cellular biochemistry - 1 Aug 2010

Carrillo-Sepúlveda M A, Barreto-Chaves M L M

Abstract excerpt

Primary cultures of vascular smooth muscle cells (VSMCs) from rats offer a good model system to examine the molecular basis of mechanism of vascular contraction-relaxation. However, during pathological conditions such as atherosclerosis and hypertension, VSMCs characteristically exhibit phenotypic modulation, change from a quiescent contractile to a proliferative synthetic phenotype, which impairs this mechanism...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aorta
Share to Cell Differentiation
Share to Mitogen-Activated Protein Kinase 3

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Muscle, Smooth, Vascular

Share to Myosin Light Chains

Share to Phosphorylation

Share to Vasoconstriction

Share to Vasodilation

Source

Identifiers

PMID: 20401736
DOI: 10.1007/s11010-010-0459-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypic modulation of cultured vascular smooth muscle cells: a functional analysis focusing on MLC and ERK1/2 phosphorylation.PMID 20401736Read ↗

An overview of potential molecular mechanisms involved in VSMC phenotypic modulation.Semantic proximity Read ↗

Characterization of transcriptional and posttranscriptional properties of native and cultured phenotypically modulated vascular smooth muscle cells.Semantic proximity Read ↗

Vascular smooth muscle remodeling in health and disease.Semantic proximity Read ↗

Elucidating VSMC phenotypic transition mechanisms to bridge insights into cardiovascular disease implicationsSemantic proximity Read ↗

Smooth muscle cell-driven vascular diseases and molecular mechanisms of VSMC plasticity.Semantic proximity Read ↗

An update on the phenotypic switching of vascular smooth muscle cells in the pathogenesis of atherosclerosis.Semantic proximity Read ↗

Disruption of actin cytoskeleton mediates loss of tensile stress induced early phenotypic modulation of vascular smooth muscle cells in organ culture.Semantic proximity Read ↗

Phenotypic Switching of Vascular Smooth Muscle Cells in Atherosclerosis.Semantic proximity Read ↗

Phenotypic switching of vascular smooth muscle cells in atherosclerosis, hypertension, and aortic dissection.Semantic proximity Read ↗

Guidelines for the isolation and characterization of murine vascular smooth muscle cells. A report from the International Society of Cardiovascular Translational Research.Semantic proximity Read ↗

[Phenotypic modulation of vascular smooth muscle cells in diabetes mellitus and intervention of traditional Chinese medicines].Semantic proximity Read ↗

Six Shades of Vascular Smooth Muscle Cells Illuminated by KLF4 (Krüppel-Like Factor 4).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.