Parallel regulation of PKC-alpha and PKC-delta characterizes the occurrence of erythroid differentiation from human primary hematopoietic progenitors.

doi:10.1016/j.exphem.2006.07.018

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Article

Parallel regulation of PKC-alpha and PKC-delta characterizes the occurrence of erythroid differentiation from human primary hematopoietic progenitors.

Experimental hematology - 1 Dec 2006

Lanuti Paola, Bertagnolo Valeria, Gaspari Anna Rita, Ciccocioppo Fausta, Pierdomenico Laura, Bascelli Adriana, Sabatino Giuseppe, Miscia Sebastiano, Marchisio Marco

Abstract excerpt

OBJECTIVE: Erythroid differentiation is a process characterized by modulation of different proteins including phosphoinositide-related enzymes such as protein kinase C (PKC) isoforms. Because in different cell lines PKC-alpha and PKC-delta have been reported to be involved in the mechanisms controlling proliferation and differentiation, the aim of this study was to examine the relative involvement of these PKC...

Topics

Cell Cycle
Cell Differentiation
Cell Division
Cell Proliferation
Cells, Cultured
Down-Regulation
Erythroid Cells
Erythropoietin
Flow Cytometry
G2 Phase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hematopoietic Stem Cells

Humans

Phenotype

Phosphorylation

Protein Kinase C-alpha

Protein Kinase C-delta

RNA, Messenger

Reverse Transcriptase Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 17157158
DOI: 10.1016/j.exphem.2006.07.018

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