Article
Parallel regulation of PKC-alpha and PKC-delta characterizes the occurrence of erythroid differentiation from human primary hematopoietic progenitors.
Experimental hematology - 1 Dec 2006
Lanuti Paola, Bertagnolo Valeria, Gaspari Anna Rita, Ciccocioppo Fausta, Pierdomenico Laura, Bascelli Adriana, Sabatino Giuseppe, Miscia Sebastiano, Marchisio Marco
Abstract excerpt
OBJECTIVE: Erythroid differentiation is a process characterized by modulation of different proteins including phosphoinositide-related enzymes such as protein kinase C (PKC) isoforms. Because in different cell lines PKC-alpha and PKC-delta have been reported to be involved in the mechanisms controlling proliferation and differentiation, the aim of this study was to examine the relative involvement of these PKC...
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