Theta class glutathione S-transferase GSTT1 genotypes and susceptibility to cervical neoplasia: interactions with GSTM1, CYP2D6 and smoking.

doi:10.1093/carcin/15.12.2841

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Article

Theta class glutathione S-transferase GSTT1 genotypes and susceptibility to cervical neoplasia: interactions with GSTM1, CYP2D6 and smoking.

Carcinogenesis - 1 Dec 1994

Warwick A, Sarhanis P, Redman C, Pemble S, Taylor J B, Ketterer B, Jones P, Alldersea J, Gilford J, Yengi L

Abstract excerpt

The factors that determine progression of cervical intra-epithelial neoplasia (CIN) to squamous cell carcinoma (SCC) are unknown. Cigarette smoking is a risk factor, suggesting polymorphism at loci that encode carcinogen-metabolizing enzymes such as glutathione S-transferase (GSTT1, GSTM1) and cy...

Topics

Adult
Carcinoma, Squamous Cell
Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme System
Female
Genetic Predisposition to Disease
Genotype
Glutathione Transferase
Humans
Leiomyoma
Menorrhagia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Mixed Function Oxygenases

Neoplasm Proteins

Risk Factors

Smoking

Uterine Cervical Neoplasms

Uterine Neoplasms

Source

Open in PubMed

Identifiers

PMID: 8001244
DOI: 10.1093/carcin/15.12.2841

Genes

GSTT1
GSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8001244-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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