Progression of cervical intraepithelial neoplasia to cervical cancer: interactions of cytochrome P450 CYP2D6 EM and glutathione s-transferase GSTM1 null genotypes and cigarette smoking.

doi:10.1038/bjc.1994.378

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Article

Progression of cervical intraepithelial neoplasia to cervical cancer: interactions of cytochrome P450 CYP2D6 EM and glutathione s-transferase GSTM1 null genotypes and cigarette smoking.

British journal of cancer - 1 Oct 1994

Warwick A P, Redman C W, Jones P W, Fryer A A, Gilford J, Alldersea J, Strange R C

Abstract excerpt

The factors that determine progression of cervical intraepithelial neoplasia (CIN) to squamous cell carcinoma (SCC) are unknown. Cigarette smoking is an independent risk factor for cervical neoplasia, suggesting that polymorphism at detoxicating enzyme loci such as cytochrome P450 CYP2D6 and glutathione S-transferase GSTM1 may determine susceptibility to these cancers. We have studied the frequencies of genotypes...

Topics

Adult
Carcinoma, Squamous Cell
Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme System
Female
Genotype
Glutathione Transferase
Humans
Isoenzymes
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Mixed Function Oxygenases

Risk Factors

Smoking

Uterine Cervical Neoplasms

Uterine Cervical Dysplasia

Source

Open in PubMed Open full text

Identifiers

PMID: 7917923
DOI: 10.1038/bjc.1994.378
PMCID: PMC2033403

Genes

GSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7917923-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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