Article
Effects of exogenous interleukin-10 in a murine model of graft-versus-host disease to minor histocompatibility antigens.
Transplantation - 15 Dec 1994
Krenger W, Snyder K, Smith S, Ferrara J L
Abstract excerpt
IL-10 is a regulatory cytokine of both T cells and monocytes. We have investigated the ability of IL-10 to regulate responses to alloantigens in vitro and in vivo. Addition of IL-10 to mixed lymphocyte cultures profoundly decreased the proliferation and IL-2 production by donor B10.BR cells stimu...
Topics
- Animals
- Antigens, Surface
- Body Weight
- Bone Marrow Transplantation
- Disease Models, Animal
- Female
- Graft vs Host Disease
- Immune Tolerance
- Interleukin-10
- Lymphocyte Activation
- Mice
- Mice, Inbred C57BL
- Mice, Inbred CBA
- Minor Histocompatibility Antigens
- Phenotype
- Spleen
- Splenomegaly
- Survival Analysis