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Article

Donor- but not host-derived interleukin-10 contributes to the regulation of experimental graft-versus-host disease

20 Jan 2012

Abstract excerpt

IL-10 is a key immune-regulatory cytokine, and its gene polymorphisms correlate with severity of clinical GVHD. IL-10 is made by a variety of donor and host cells, but the functional relevance of its source and its role in the biology of acute GVHD are not well understood. We used preclinical models to examine the relevance of IL-10(-/-) in donor and host cellular subsets on the severity of GVHD. IL-10(-/-) in...

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PMID: 22262800
DOI: 10.1189/jlb.1011510

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