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Amyloid β-peptide is produced by cultured cells during normal metabolism: A reprise

27 Jul 2006

Abstract excerpt

In the twenty years since George Glenner identified the amyloid beta-protein (Abeta), advances in understanding the biochemical pathology, genetics and cell biology of Alzheimer's disease have led to a detailed molecular hypothesis for the genesis of AD and brought us into human trials of anti-amyloid agents. The ability to study Abeta dynamically in cultured cells and in vivo derives from the recognition in 1992...

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PMID: 16914855
DOI: 10.3233/jad-2006-9s319

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