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Article

Loss of NOTCH2 Positively Predicts Survival in Subgroups of Human Glial Brain Tumors

27 Jun 2007

Abstract excerpt

The structural complexity of chromosome 1p centromeric region has been an obstacle for fine mapping of tumor suppressor genes in this area. Loss of heterozygosity (LOH) on chromosome 1p is associated with the longer survival of oligodendroglioma (OD) patients. To test the clinical relevance of 1p loss in glioblastomas (GBM) patients and identifiy the underlying tumor suppressor locus, we constructed a somatic...

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PMID: 17593975
DOI: 10.1371/journal.pone.0000576

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Research trail→

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Loss of NOTCH2 Positively Predicts Survival in Subgroups of Human Glial Brain TumorsPMID 17593975Read ↗

Two types of chromosome 1p losses with opposite significance in gliomasSemantic proximity Read ↗

Molecular analysis of chromosome 1 abnormalities in human gliomas reveals frequent loss of 1p in oligodendroglial tumors.Semantic proximity Read ↗

Identification of a consistent region of allelic loss on 1p32 in meningiomas: correlation with increased morbidity.Semantic proximity Read ↗

1p36 is a preferential target of chromosome 1 deletions in astrocytic tumours and homozygously deleted in a subset of glioblastomasSemantic proximity Read ↗

Integrated multi-omics analysis of oligodendroglial tumours identifies three subgroups of 1p/19q co-deleted gliomasSemantic proximity Read ↗

Allelic losses at 1p36 and 19q13 in gliomas: correlation with histologic classification, definition of a 150-kb minimal deleted region on 1p36, and evaluation of CAMTA1 as a candidate tumor suppressor gene.Semantic proximity Read ↗

Whole-genomic survey of oligodendroglial tumors: correlation between allelic imbalances and gene expression profiles.Semantic proximity Read ↗

Oligodendroglial Tumors: Refinement of Candidate Regions on Chromosome Arm 1p and Correlation of 1p/19q Status with SurvivalSemantic proximity Read ↗

Localization of common deletion regions on 1p and 19q in human gliomas and their association with histological subtypeSemantic proximity Read ↗

Identification of two distinct deleted regions on the short arm of chromosome 1 and rare mutation of the CDKN2C gene from 1p32 in oligodendroglial tumors.Semantic proximity Read ↗

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