In vitro maturation of prehead-like bacteriophage T4 polyheads: structural changes accompanying proteolytic cleavage and lattice expansion.

doi:10.1006/jsbi.1994.1021

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Article

In vitro maturation of prehead-like bacteriophage T4 polyheads: structural changes accompanying proteolytic cleavage and lattice expansion.

Journal of structural biology - 1 Jan 2000

Müller M, Mesyanzhinov V V, Aebi U

Abstract excerpt

We have studied cleavage and expansion of the major T4 phage capsid protein gp23 (56 kDa) using polyheads, an aberrant, polymorphic tubular variant of bacteriophage T4D, as a model system. In a first step, we have cleaved the 65-amino-acid-long amino-terminal "delta piece" by limited proteolysis...

Topics

Bacteriophage T4
Capsid
Escherichia coli
Genetic Variation
Microscopy, Electron
Models, Structural
Polymorphism, Genetic
Serine Endopeptidases
Staphylococcus aureus

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