Article
Molecular Dissection of the Forces Responsible for Viral Capsid Assembly and Stabilization by Decoration Proteins.
Biochemistry - 7 Feb 2017
Lambert Shannon, Yang Qin, De Angeles Rolando, Chang Jenny R, Ortega Marcos, Davis Christal, Catalano Carlos Enrique
Abstract excerpt
Complex double-stranded DNA viruses utilize a terminase enzyme to package their genomes into a preassembled procapsid shell. DNA packaging triggers a major conformational change in the proteins assembled into the shell and most often subsequent addition of a decoration protein that is required to stabilize the structure. In bacteriophage λ, DNA packaging drives a procapsid expansion transition to afford a larger...
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