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Article

Crosslinking renders bacteriophage HK97 capsid maturation irreversible and effects an essential stabilization.

The EMBO journal - 6 Apr 2005

Ross Philip D, Cheng Naiqian, Conway James F, Firek Brian A, Hendrix Roger W, Duda Robert L, Steven Alasdair C

Abstract excerpt

In HK97 capsid maturation, structural change ('expansion') is accompanied by formation of covalent crosslinks, connecting residue K169 in the 'E-loop' of each subunit with N356 on another subunit. We show by complementation experiments with the K169Y mutant, which cannot crosslink, that crosslinking is an essential function. The precursor Prohead-II passes through three expansion intermediate (EI) states en route...

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Identifiers

PMID: 15775971
DOI: 10.1038/sj.emboj.7600613
PMCID: PMC1142538

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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