Article
Structural and functional similarities between the capsid proteins of bacteriophages T4 and HK97 point to a common ancestry.
Proceedings of the National Academy of Sciences of the United States of America - 17 May 2005
Fokine Andrei, Leiman Petr G, Shneider Mikhail M, Ahvazi Bijan, Boeshans Karen M, Steven Alasdair C, Black Lindsay W, Mesyanzhinov Vadim V, Rossmann Michael G
Abstract excerpt
Gene product (gp) 24 of bacteriophage T4 forms the pentameric vertices of the capsid. Using x-ray crystallography, we found the principal domain of gp24 to have a polypeptide fold similar to that of the HK97 phage capsid protein plus an additional insertion domain. Fitting gp24 monomers into a cryo-EM density map of the mature T4 capsid suggests that the insertion domain interacts with a neighboring subunit,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.