Article
Glutathione S-transferase Mu phenotype in patients with familial adenomatous polyposis and in unaffected controls.
Cancer detection and prevention - 1 Jan 1994
Spigelman A D, Nugent K P, Penna C, Foulds S, Phillips R K
Abstract excerpt
Patients with familial adenomatous polyposis (FAP) are at high risk for duodenal tumors, the distribution of which suggests that bile is important in their development. Studies of the bile of FAP patients suggest that it contains an excess of active carcinogens. Defective hepatic metabolism of ca...
Topics
- Adenomatous Polyposis Coli
- Adolescent
- Adult
- Aged
- Female
- Glutathione Transferase
- Humans
- Isoenzymes
- Male
- Middle Aged
- Phenotype