Article
Detoxification enzyme polymorphisms are not involved in duodenal adenomatosis in familial adenomatous polyposis.
The British journal of surgery - 1 Apr 2008
Berkhout M, Roelofs H M J, te Morsche R H M, Dekker E, van Krieken J H J M, Nagengast F M, Peters W H M
Abstract excerpt
BACKGROUND: Patients with familial adenomatous polyposis (FAP) are at high risk of developing duodenal adenomas and carcinomas. Besides germline mutations in the adenomatous polyposis coli (APC) gene, additional factors may influence the age of onset and number of duodenal adenomas. This study compared the genotype distributions of duodenal detoxification enzyme isoforms in patients with FAP and controls....
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