Clustered base substitutions in CTP synthetase conferring drug resistance in Chinese hamster ovary cells.

doi:10.1038/ng0493-317

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Article

Clustered base substitutions in CTP synthetase conferring drug resistance in Chinese hamster ovary cells.

Nature genetics - 1 Apr 1993

Whelan J, Phear G, Yamauchi M, Meuth M

Abstract excerpt

Dominantly acting mutations that eliminate the allosteric regulation of CTP synthetase confer a form of multidrug resistance and a mutator phenotype to cultured Chinese hamster ovary cells. Mutations responsible for this phenotype have been identified in 23 independent strains selected for resist...

Topics

Animals
Base Sequence
CHO Cells
Carbon-Nitrogen Ligases
Cloning, Molecular
Conserved Sequence
Cricetinae
Cytarabine
DNA Primers
DNA, Complementary
Drug Resistance
Fluorouracil
Gene Expression
Humans
Ligases
Molecular Sequence Data
Phenotype
Point Mutation

Source

Open in PubMed

Identifiers

PMID: 7981751
DOI: 10.1038/ng0493-317

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7981751-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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