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Article

IL-4 VNTR gene polymorphism in chronic polyarthritis. The rare allele is associated with protection against destruction.

Rheumatology (Oxford, England) - 1 Oct 2000

Buchs N, Silvestri T, di Giovine F S, Chabaud M, Vannier E, Duff G W, Miossec P

Abstract excerpt

OBJECTIVE: To evaluate the occurrence of variants of the interleukin 4 (IL-4) and IL-4 receptor (IL-4R) genes in patients with rheumatoid arthritis (RA) and their possible contribution to joint destruction. METHODS: Allelic frequencies for polymorphisms in the IL-4 [variable number of tandem repeat (VNTR) polymorphism in intron 3] and IL-4 receptor alpha chain (transition at nucleotide 1902) genes were assessed...

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PMID: 11035134
DOI: 10.1093/rheumatology/39.10.1126

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