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Article

Brk is coamplified with ErbB2 to promote proliferation in breast cancer

21 Aug 2008

Abstract excerpt

Amplification of the receptor tyrosine kinase ErbB2 is frequently observed in breast cancer. Amplification of erbB2 is also associated with multiple genomic gains and losses; however, the importance of these associated changes is largely unknown. We demonstrate that Brk, a cytoplasmic tyrosine kinase, is coamplified and coexpressed with ErbB2 in human breast cancers. ErbB2 interacts with Brk and increases its...

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PMID: 18719096
DOI: 10.1073/pnas.0805009105

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