Article
P53 and mdm-2: interactions between tumor suppressor gene and oncogene products.
The Mount Sinai journal of medicine, New York - 1 Sept 1994
Perry M E, Levine A J
Abstract excerpt
The p53 tumor suppressor gene is the most commonly mutated gene in human cancers and, although mutation leads to loss of p53 suppression of cell growth, it can also result in new functions which enhance tumorigenicity. These mutations often lead to loss of p53 transcriptional activation activity, which is likely to account for the loss of growth control. The p53 protein induces expression of the GADD45 and mdm-2...
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