Article
The attenuation phenotype conferred by the M gene of the influenza A/Ann Arbor/6/60 cold-adapted virus (H2N2) on the A/Korea/82 (H3N2) reassortant virus results from a gene constellation effect.
Virus research - 1 Sept 1992
Subbarao E K, Perkins M, Treanor J J, Murphy B R
Abstract excerpt
A single gene reassortant (SGR) virus that derived its M gene from the attenuated influenza A/Ann Arbor/6/60 cold-adapted (CA) donor virus and the remaining genes from the A/Korea/82 (H3N2) wild type (WT) virus (designated A/Korea/82 CA M-SGR) was previously shown to be attenuated in mice, hamste...
Topics
- Adaptation, Physiological
- Animals
- Base Sequence
- Cold Temperature
- Cricetinae
- DNA, Viral
- Female
- Genes, Viral
- Humans
- Influenza A Virus, H2N2 Subtype
- Influenza A Virus, H3N2 Subtype
- Influenza A virus
- Influenza Vaccines
- Mice
- Molecular Sequence Data
- Phenotype
- Vaccines, Attenuated
- Virus Replication